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PXD015645

PXD015645 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal lysine crotonylation profiling in the livers of mice
DescriptionCrotonylation (Cr) is a novel post-transcriptional modification with the potential to regulate multiple biological processes. In order to improve the crotonylation dataset for further study, we performed LC-MS/MS with mouse liver samples to obtain the in vivo crotonylome. Totally, we identified 4607 unique crotonylated peptides in 1322 proteins. The motifs KcrE, KcrD and EKcr were significantly enriched with the crotonylated peptides whose localization probability was over 0.75. The identified crotonylated proteins were mostly located in cytoplasm and nucleus, and most crotonylated proteins were enzymes. Functional enrichment analysis based on GO and KEGG pathway showed that, crotonylated proteins were closely related to small molecule catabolic process, purine-containing compound metabolic process, carbon metabolism pathway, ribosome pathway and a series of metabolism associated biological processes. In conclusion, this research provided the largest in vivo dataset of crotonylome and the first crotonylome of mouse liver. We offered another evidence that crotonylation widely existed in non-histone proteins and was probably involved in various biological processes.
HostingRepositoryiProX
AnnounceDate2020-01-19
AnnouncementXMLSubmission_2023-08-27_21:05:04.924.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiangfeng Liu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListcrotonaldehyde - site K
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-09-30 06:35:25ID requested
12023-08-27 21:05:06announced
Publication List
Liu JF, Wu SF, Liu S, Sun X, Wang XM, Xu P, Chen HZ, Yang JT, Global Lysine Crotonylation Profiling of Mouse Liver. Proteomics, 20(19-20):e2000049(2020) [pubmed]
Keyword List
submitter keyword: Crotonylation, Liver, Dataset, Mouse
Contact List
Juntao Yang
contact affiliationPeking Union Medical College
contact emailyangjt@pumc.edu.cn
lab head
Jiangfeng Liu
contact affiliationPeking Union Medical College
contact emailliujiangf@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI