PXD015610

PXD015610 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of brain region and gender-specific synaptic protein expression in the adult mouse brain
Description	In a wide range of synaptopathies a sex/gender bias in prevalence and clinical course has been reported. Therefore, analysis of the synaptic proteinaceous inventory in different brain regions in males and females is very desirable in understanding the molecular basis of brain function and the etiology of its diseases. In this study we analyzed the synaptic proteome of the prefrontal cortex, hippocampus, striatum and cerebellum in male and female mice. Our efforts should serve as a neurobiological framework to better understand the regional and sex/gender-specific synaptic function both in health and disease.
HostingRepository	PRIDE
AnnounceDate	2020-02-19
AnnouncementXML	Submission_2020-02-19_10:02:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Malte Sielaff
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-26 23:34:43	ID requested
⏵ 1	2020-02-19 10:02:35	announced

Distler U, Schumann S, Kesseler HG, Pielot R, Smalla KH, Sielaff M, Schmeisser MJ, Tenzer S, Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain. Cells, 9(2):(2020) [pubmed]

curator keyword: Biological

submitter keyword: data-independent acquisition, label-free quantification, synaptic junction, prefrontal cortex, hippocampus, striatum, cerebellum, sex/gender bias

Stefan Tenzer
contact affiliation	University Medical Center Mainz Insitute for Immunology Langenbeckstr. 1, 55118 Mainz, Germany
contact email	tenzer@uni-mainz.de
lab head
Malte Sielaff
contact affiliation	University Medical Center Mainz
contact email	malte.sielaff@uni-mainz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD015610

PRIDE project URI

• PRIDE
  1. PXD015610
     1. Label: PRIDE project
     2. Name: Proteomic analysis of brain region and gender-specific synaptic protein expression in the adult mouse brain