PXD015607

PXD015607 is an original dataset announced via ProteomeXchange.

Title	Pericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling
Description	Patients with aortic stenosis are often indicated to aortic valve replacement to relief pressure overload. After surgery, patients experience a myocardial response commonly known as reverse remodeling, where structural and functional recovery are expected. Notwithstanding, some patients exhibit an incomplete response, whose biological mechanisms remain poorly understood. The pericardial fluid can be safely collected during valve replacement and its proteome composition reflects heart’s pathophysiological status. Taking this into account, we characterized pericardial fluid proteome of patients with complete and incomplete reverse remodeling following a shotgun LC-MS/MS (Orbitrap Q Exactive HF MS) approach. We aimed to improve the current understanding of the mechanisms underlying an incomplete reverse remodeling and to pinpoint surrogate prognostic markers for this condition. In the future, this data can be important to develop tools for early prognosis of incomplete reverse remodeling and to adjust medical/pharmacological therapies to maximize recovery.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:36:44.427.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fábio Trindade
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-26 04:41:34	ID requested
1	2022-05-25 03:09:47	announced
⏵ 2	2024-10-22 05:36:45	announced	2024-10-22: Updated project metadata.

Frag, ã, o-Marques M, Vitorino R, Barroso I, Falc, ã, o-Pires I, Leite-Moreira A, Trindade F, Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis. J Pers Med, 12(2):(2022) [pubmed]

10.3390/jpm12020264;

submitter keyword: Human, Coronary Artery Disease, Aortic Stenosis, Pericardial Fluid, Reverse Remodeling

Rui Vitorino
contact affiliation	iBiMED – Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal; UnIC – Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
contact email	rvitorino@ua.pt
lab head
Fábio Trindade
contact affiliation	iBiMED, University of Aveiro; UnIC, Faculty of Medicine, University of Porto
contact email	fabiotrindade@ua.pt
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD015607

PRIDE project URI

• PRIDE
  1. PXD015607
     1. Label: PRIDE project
     2. Name: Pericardial fluid proteome profile in aortic stenosis patients with complete or incomplete reverse remodeling