PXD015604

PXD015604 is an original dataset announced via ProteomeXchange.

Title	Severe asthmatic bronchial smooth muscle decreases epithelial response to rhinovirus infection.
Description	Asthma is a very frequent airway disease that affects 6 to 20% of the population. Severe asthma, represents 3 to 5% of all asthmatic patients and is histologically characterized by an increased bronchial smooth muscle (BSM) mass and clinically by viral exacerbations. Functionally, BSM remodeling had a poor prognostic value in asthma, since higher BSM mass was associated with lower lung function and increased exacerbation rate. However, the role of BSM as a potential actor of asthma exacerbation has only been sparsely suggested. We thus hypothesis that asthmatic BSM cells could act on bronchial epithelium and modified its response to rhinovirus infection.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:18.752.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dupuy Jean-William
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-26 02:13:51	ID requested
1	2023-05-02 03:01:24	announced
⏵ 2	2023-11-14 08:45:19	announced	2023-11-14: Updated project metadata.

Esteves P, Allard B, Celle A, Dupin I, Maurat E, Ousova O, Thumerel M, Dupuy JW, Leste-Lasserre T, Marthan R, Girodet PO, Trian T, Berger P, Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium. Cell Rep, 38(13):110571(2022) [pubmed]

submitter keyword: epithelium, smooth muscle cells,Asthma

Thomas Trian
contact affiliation	U1045, CRCTB, Bâtiment PTIB, Avenue de Haut Lévèque, 33000 Bordeaux, France
contact email	thomas.trian@u-bordeaux.fr
lab head
Dupuy Jean-William
contact affiliation	Plateforme Proteome Bordeaux
contact email	jean-william.dupuy@u-bordeaux.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD015604

PRIDE project URI

• PRIDE
  1. PXD015604
     1. Label: PRIDE project
     2. Name: Severe asthmatic bronchial smooth muscle decreases epithelial response to rhinovirus infection.