PXD015548

PXD015548 is an original dataset announced via ProteomeXchange.

Title	Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans
Description	The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to nonmethylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between C. elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex.
HostingRepository	PRIDE
AnnounceDate	2019-09-27
AnnouncementXML	Submission_2019-10-25_03:55:26.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015548
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-23 04:00:45	ID requested
1	2019-09-27 06:30:33	announced
⏵ 2	2019-10-25 03:55:28	announced	2019-10-25: Updated publication reference for PubMed record(s): 31602465.

Beurton F, Stempor P, Caron M, Appert A, Dong Y, Chen RA, Cluet D, Cout, é Y, Herbette M, Huang N, Polveche H, Spichty M, Bedet C, Ahringer J, Palladino F, Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans. Nucleic Acids Res, 47(21):11164-11180(2019) [pubmed]

submitter keyword: Chromatin, C. elegans, SET1/COMPASS complex, Interactomics

Virginie Brun
contact affiliation	EDyP
contact email	virginie.brun@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD015548

PRIDE project URI

• PRIDE
  1. PXD015548
     1. Label: PRIDE project
     2. Name: Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans