PXD015527
PXD015527 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative proteomics of macrophage in response to LPS stimulation |
| Description | PTM proteomics had been increasingly used in studies related to inflammation and immunity, but the integrated analysis of multiple PTM was lacking. Here, we integrated WCP, acetylome, phosphoproteome and ubiquitinome datasets to identify LPS stimulation-dependent PTM events in macrophages with or without MG132. Using the SILAC quantification, we successfully identified 53,785 PTM sites and 19,726 proteins at all times in LPS-stimulated macrophages. Integration of these datasets provided a possibility to have a more comprehensive understanding of the inflammatory response. |
| HostingRepository | iProX |
| AnnounceDate | 2019-09-20 |
| AnnouncementXML | Submission_2021-06-27_18:23:20.036.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Feiyang Ji |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue; phosphorylated residue; ubiquitination signature dipeptidyl lysine |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-09-21 03:04:53 | ID requested | |
| ⏵ 1 | 2021-06-27 18:23:20 | announced |
Publication List
| Ji F, Zhou M, Zhu H, Jiang Z, Li Q, Ouyang X, Lv Y, Zhang S, Wu T, Li L, Integrative Proteomic Analysis of Multiple Posttranslational Modifications in Inflammatory Response. Genomics Proteomics Bioinformatics, 20(1):163-176(2022) [pubmed] |
Keyword List
| submitter keyword: ubiquitinome, acetylome, phosphoproteome, inflammation |
Contact List
| Lanjuan Li | |
|---|---|
| contact affiliation | State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University |
| contact email | ljli@zju.edu.cn |
| lab head | |
| Feiyang Ji | |
| contact affiliation | State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University |
| contact email | feiyangji@zju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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