PXD015462

PXD015462 is an original dataset announced via ProteomeXchange.

Title	Acute Pulmonary and Serologic Changes in the Proteomes of Bromine Exposed Mice (lungdata)
Description	Bromine is the most common organohalide found in nature. This halogen is often produced from sea brines and salt lakes. The primary producers and consuming countries of Br2 include the USA, Israel, Jordon, and China. The production of many products including brominated fire retardants (BFR’s), in addition to drilling fluids, agricultural materials, and biocides for the treatment of water all require Br2. While accidental exposure has occurred during production processes and transportation, a major concern is that larger storehouses of Br2 are potential targets for terrorist groups throughout the World. Higher concentrations of Br2 are life threatening within as little as 30 minutes. In our present study, we utilized the common C57BL/6 mouse model to survey the lung and serologic proteomes following exposure to near lethal levels of Br2 for 30 minutes. We describe detailed acute changes found within the global proteomes of these animals, in addition to post-translationally modified brominated proteins longitudinally over three time points from 30min to 96hrs post exposure. Through the application of common proteomics workflows combined with systems biology analysis, we were able to identify robust and highly significant biomarkers and pathways associated with Br2 exposure that are new to this model.
HostingRepository	PRIDE
AnnounceDate	2020-06-18
AnnouncementXML	Submission_2020-06-17_16:24:30.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD015462
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	james mobley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Bromo; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-16 03:44:48	ID requested
⏵ 1	2020-06-17 16:24:30	announced

Dataset with its publication pending

submitter keyword: Bromine/ Lung/ Sera/ GeLC/ nLC-ESI-MS2/ Proteomics/ Discovery/ Systems Biology

James Mobley
contact affiliation	University of Alabama at Birmingham
contact email	mobleyja@uab.edu
lab head
james mobley
contact affiliation	University of Alabama at Birmingham
contact email	mobleyja@uab.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015462
     1. Label: PRIDE project
     2. Name: Acute Pulmonary and Serologic Changes in the Proteomes of Bromine Exposed Mice (lungdata)