PXD015450

PXD015450 is an original dataset announced via ProteomeXchange.

Title	A Systems biology approach for defining the potential molecular framework of hypereosinophilic syndrome with cutaneous involvement
Description	Hypereosinophilic syndrome (HES) is a rare multisystem disease that predominantly includes skin with severe and persistent itching. A lack of understanding about the pathological condition and mechanism of dermatosis caused by HES hinders its treatment. In the present study, we applied a quantitative proteomics approach to characterize the cellular responses of skin tissue to HES at the proteome level. We identified hundreds of skin tissue proteins that were differentially expressed between HES patients and healthy individuals. HES patients display severely damaged microenvironment, including extracellular matrix (ECM) organization and disassembly, immune disorders, decreased metabolic capacity, and susceptibility to microbial infection. Moreover, there was abnormal proliferation of basal epidermal stem cells, which was closely related to high expression of the epigenetic regulator, histone deacetylase 2, providing mechanistic insight into the abnormal epidermal thickening of HES skin tissues. Overall, our study provides a comprehensive framework for a system-level understanding of HES-induced dermatosis tissues at the protein and cell pathway levels. Our findings may facilitate a new approach to diagnosis and treatment to alleviate skin clinical symptoms, monitor the activity of HES, and determine therapeutic effects.
HostingRepository	iProX
AnnounceDate	2020-02-18
AnnouncementXML	Submission_2020-02-18_00:39:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenjuan Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-15 22:18:40	ID requested
⏵ 1	2020-02-18 00:39:18	announced

Wang W, Ma J, Sun X, Ba W, Meng X, Zhu Y, Leng L, Li C, A systems biology approach for defining the potential molecular framework of idiopathic hypereosinophilic syndrome with cutaneous involvement. Biochem Biophys Res Commun, 524(3):567-574(2020) [pubmed]

submitter keyword: idiopathic hypereosinophilic syndrome, epidermal stem cells, proteomics

Ling Leng
contact affiliation	Peking Union Medical College Hospital.
contact email	zhenlinger@126.com
lab head
Wenjuan Wang
contact affiliation	Department of Dermatology, PLA General Hospital
contact email	phenix123@126.com
dataset submitter

iProX dataset URI