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PXD015450

PXD015450 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Systems biology approach for defining the potential molecular framework of hypereosinophilic syndrome with cutaneous involvement
DescriptionHypereosinophilic syndrome (HES) is a rare multisystem disease that predominantly includes skin with severe and persistent itching. A lack of understanding about the pathological condition and mechanism of dermatosis caused by HES hinders its treatment. In the present study, we applied a quantitative proteomics approach to characterize the cellular responses of skin tissue to HES at the proteome level. We identified hundreds of skin tissue proteins that were differentially expressed between HES patients and healthy individuals. HES patients display severely damaged microenvironment, including extracellular matrix (ECM) organization and disassembly, immune disorders, decreased metabolic capacity, and susceptibility to microbial infection. Moreover, there was abnormal proliferation of basal epidermal stem cells, which was closely related to high expression of the epigenetic regulator, histone deacetylase 2, providing mechanistic insight into the abnormal epidermal thickening of HES skin tissues. Overall, our study provides a comprehensive framework for a system-level understanding of HES-induced dermatosis tissues at the protein and cell pathway levels. Our findings may facilitate a new approach to diagnosis and treatment to alleviate skin clinical symptoms, monitor the activity of HES, and determine therapeutic effects.
HostingRepositoryiProX
AnnounceDate2020-02-18
AnnouncementXMLSubmission_2020-02-18_00:39:16.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWenjuan Wang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-09-15 22:18:40ID requested
12020-02-18 00:39:18announced
Publication List
Wang W, Ma J, Sun X, Ba W, Meng X, Zhu Y, Leng L, Li C, A systems biology approach for defining the potential molecular framework of idiopathic hypereosinophilic syndrome with cutaneous involvement. Biochem Biophys Res Commun, 524(3):567-574(2020) [pubmed]
Keyword List
submitter keyword: idiopathic hypereosinophilic syndrome, epidermal stem cells, proteomics
Contact List
Ling Leng
contact affiliationPeking Union Medical College Hospital.
contact emailzhenlinger@126.com
lab head
Wenjuan Wang
contact affiliationDepartment of Dermatology, PLA General Hospital
contact emailphenix123@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI