PXD015398

PXD015398 is an original dataset announced via ProteomeXchange.

Title	Impact of abacavir and abacavir analogues on HLA-B*57:01 peptide presentation
Description	Characterisation of peptide ligands of the Major histocompatibility class (MHC) I allele, HLA-B*57:01, expressed in the C1R (Class I reduced) B-lymphoblastoid cell line, after exposure to the anti-retroviral abacavir or abacavir analogues.
HostingRepository	PRIDE
AnnounceDate	2019-11-27
AnnouncementXML	Submission_2020-01-13_23:57:31.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patricia Illing
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dehydrated residue; phosphorylated residue; monohydroxylated residue; deamidated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-10 07:36:29	ID requested
1	2019-10-03 08:41:53	announced
2	2019-11-27 06:53:11	announced	2019-11-27: Updated project metadata.
⏵ 3	2020-01-13 23:57:33	announced	2019-11-27: Updated project metadata. 2020-01-14: Updated publication reference for PubMed record(s): 31549414.

Thomson PJ, Illing PT, Farrell J, Alhaidari M, Bell CC, Berry N, O'Neill PM, Purcell AW, Park KB, Naisbitt DJ, Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation. Allergy, 75(3):636-647(2020) [pubmed]

submitter keyword: HLA-B*57:01, Immunopeptidome, MHC, LC-MSMS, abacavir

Anthony W. Purcell
contact affiliation	Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
contact email	anthony.purcell@monash.edu
lab head
Patricia Illing
contact affiliation	Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia
contact email	patricia.illing@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD015398

PRIDE project URI

• PRIDE
  1. PXD015398
     1. Label: PRIDE project
     2. Name: Impact of abacavir and abacavir analogues on HLA-B*57:01 peptide presentation