PXD015386 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism |
Description | Conventional treatments for inflammatory bowel disease (IBD) have multiple potential side effects. Therefore, alternative treatments are desperately needed. In the present study, we proposed a new therapeutic tool for the treatment of IBD in murine pre-clinical models by using MSC-Exos. We demonstrated that the infused MSC-Exos are immunotolerated by the host, which is convenient for a future clinical application of MSC-Exos in IBD. To understand the molecular basis mediating the anticolitic benefit of MSC-Exos, we performed proteomic analysis using iTRAQ technology to detect the protein expression profiles in MSC-Exos and the corresponding supernatants from their parent cell MSCs. Proteomic analysis revealed that MSC-Exos were enriched in proteins involved in regulating multiple biological processes associated with the anti-colitic benefit of MSC-Exos. Particularly, metallothionein-2 in MSC-Exos was required for the suppression of inflammatory responses in macrophages. Taken together, MSC-Exos are critical regulators of inflammatory responses and may be promising candidates for IBD treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:05:34.057.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ping Lan |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-09-10 01:40:30 | ID requested | |
1 | 2020-05-26 15:22:04 | announced | |
⏵ 2 | 2024-10-22 05:05:40 | announced | 2024-10-22: Updated project metadata. |
Publication List
Liu H, Liang Z, Wang F, Zhou C, Zheng X, Hu T, He X, Wu X, Lan P, Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism. JCI Insight, 4(24):(2019) [pubmed] |
10.1172/jci.insight.131273; |
Keyword List
submitter keyword: Inflammatory bowel disease, exosomes, macrophages, mesenchymal stromal cells |
Contact List
Ping Lan |
contact affiliation | 1.Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 2.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. |
contact email | lanping@mail.sysu.edu.cn |
lab head | |
Ping Lan |
contact affiliation | The Sixth Affiliated Hospital, Sun Yat-sen University |
contact email | lanping@mail.sysu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015386
- Label: PRIDE project
- Name: Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism