PXD015358

PXD015358 is an original dataset announced via ProteomeXchange.

Title	Human Cerebrospinal fluid LC-MSMS
Description	Chronic Traumatic Encephalopathy (CTE) is a tauopathy that affects individuals with a history of repetitive mild traumatic brain injury, such as American football players. Initial neuropathologic changes in CTE include perivascular deposition of phosphorylated microtubule-associated protein tau (p-tau) neurofibrillary tangles and other aggregates in neurons, astrocytes and cell processes in an irregular pattern often at the depths of the cortical sulci. In later stages, the p-tau depositions become widespread and is associated with neurodegeneration. Extracellular vesicles (EVs) are known to carry neuropathogenic molecules, most notably p-tau. We therefore examined the protein composition of EVs isolated from the cerebrospinal fluid (CSF) of former National Football League (NFL) players with cognitive and neuropsychiatric dysfunction, and an age-matched control group (CTRL) with no history of contact sports or traumatic brain injury.
HostingRepository	PRIDE
AnnounceDate	2019-10-30
AnnouncementXML	Submission_2019-10-30_02:26:41.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Satoshi Muraoka
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-09 02:50:17	ID requested
⏵ 1	2019-10-30 02:26:44	announced

Muraoka S, Jedrychowski MP, Tatebe H, DeLeo AM, Ikezu S, Tokuda T, Gygi SP, Stern RA, Ikezu T, Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Front Neurosci, 13():1059(2019) [pubmed]

submitter keyword: chronic traumatic encephalopathy, cerebrospinal fluid, extracellular vesicles, TMT label, LC-MSMSMS

Tsuneya Ikezu
contact affiliation	Departments of Pharmacology & Experimental Therapeutics and Neurology, Laboratory of Molecular NeuroTherapeutics, Boston University School of Medicine
contact email	tikezu@bu.edu
lab head
Satoshi Muraoka
contact affiliation	Boston University School of Medicine
contact email	smuraoka@bu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD015358

PRIDE project URI

• PRIDE
  1. PXD015358
     1. Label: PRIDE project
     2. Name: Human Cerebrospinal fluid LC-MSMS