PXD015354

PXD015354 is an original dataset announced via ProteomeXchange.

Title	H3K4me2 regulates the recovery of protein biosynthesis and homeostasis from UV-induced DNA damage during development and aging
Description	DNA damage causes cancer, impairs development and accelerates aging. UV irradiation induces transcription-blocking lesions and defects in transcription-coupled nucleotide excision repair lead to developmental failure and premature aging in humans. Following DNA repair, the homeostatic processes need to be reestablished to ensure development and maintain tissue functionality. Here, we report that in C. elegans removal of the MLL/COMPASS H3K4 methyltransferase exacerbates the developmental growth retardation and accelerates aging, while depletion of the H3K4 demethylase, SPR-5, promotes developmental growth and extends lifespan amid UV-induced damage. We demonstrate that specifically the DDR-induced H3K4me2 is associated with the activation of genes regulating RNA transport, splicing, ribosome biogenesis, and protein homeostasis and regulates the recovery of protein biosynthesis that is essential for survival of UV-induced DNA damage. Our study uncovers a role of H3K4me2 in coordinating the recovery of protein biosynthesis and homeostasis that is required for developmental growth and longevity after DNA damage.
HostingRepository	PRIDE
AnnounceDate	2020-10-13
AnnouncementXML	Submission_2020-10-18_22:44:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Meyer
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-09 01:54:29	ID requested
1	2020-10-13 01:14:31	announced
⏵ 2	2020-10-18 22:44:24	announced	2020-10-19: Updated publication reference for PubMed record(s): 33046905.

Wang S, Meyer DH, Schumacher B, H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol, 27(12):1165-1177(2020) [pubmed]

curator keyword: Biological

submitter keyword: H3K4me2, C. elegans, UV, DNA damage

Univ.-Prof. Dr. Björn Schumacher
contact affiliation	CECAD Research Center Institute for Genome Stability in Aging and Disease University of Cologne
contact email	bjoern.schumacher@uni-koeln.de
lab head
David Meyer
contact affiliation	CECAD Research Center
contact email	david.meyer@uni-koeln.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015354
     1. Label: PRIDE project
     2. Name: H3K4me2 regulates the recovery of protein biosynthesis and homeostasis from UV-induced DNA damage during development and aging