PXD015340

PXD015340 is an original dataset announced via ProteomeXchange.

Title	MuRF1 mediated ubiquitination of M-line Titin
Description	MuRF1 mediated ubiquitination of titin promotes autophagy machinery recruitment onto titin. Titin ubiquitination appears dynamically regulated by myofibrillar stretch via the unfolding of an NL linker sequence, leading to different ubiquitination patterns of the chain. This mechanism might be compromised in the titin SNP rs 200675195, a possible factor in cardiomyopathy.
HostingRepository	PRIDE
AnnounceDate	2021-06-23
AnnouncementXML	Submission_2021-06-22_22:56:16.462.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Barbara Franke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-06 06:19:58	ID requested
⏵ 1	2021-06-22 22:56:16	announced

Dataset with its publication pending

submitter keyword: ubiquitination, MuRF1, Titin

Olga Mayans
contact affiliation	University of Konstanz, Department of Biology, Biophysics & Structural Biology, Germany
contact email	olga.mayans@uni-konstanz.de
lab head
Barbara Franke
contact affiliation	University of Konstanz
contact email	barbara.franke@uni-konstanz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD015340

PRIDE project URI

• PRIDE
  1. PXD015340
     1. Label: PRIDE project
     2. Name: MuRF1 mediated ubiquitination of M-line Titin