We have included human samples including bladder tissue, Cervical tissue, Colorectal tissue, diffuse large B-cell lymphoma, Gastric tissue, glioblastoma multiforme, K562 cell, thyroid tissue, Plasma, Leukemia, Sarcoma, squamous cell lung carcinoma, hepatocellular K562 cell lines. The details are described in Table 1 and Supplementary Table 1.