PXD015239

PXD015239 is an original dataset announced via ProteomeXchange.

Title	Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease
Description	Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson's disease (PD), but its molecular determinants are unknown. Here, we determine epigenetic changes and genes involved in hemispheric asymmetry in the healthy and PD brain. Neurons of healthy individuals exhibit numerous hemispheric differences in DNA methylation, affecting genes implicated in neurodegenerative diseases. In PD patients, hemispheric asymmetry in DNA methylation is even greater and involves many PD risk genes. Moreover, the lateralization of clinical PD symptoms involves epigenetic, transcriptional, and proteomic differences across hemispheres that affect neurodevelopment, immune activation, and synaptic transmission. In aging, healthy neurons demonstrate a progressive loss of hemisphere asymmetry in epigenomes that is amplified in PD. For PD patients, a long disease course is associated with retaining more hemispheric asymmetry in neuronal epigenomes. Hemispheric differences in epigenetic gene regulation are prevalent in neurons and may affect the progression and symptoms of PD.
HostingRepository	PRIDE
AnnounceDate	2020-03-26
AnnouncementXML	Submission_2020-03-26_00:11:53.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PEIPEI LI
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-30 01:57:18	ID requested
⏵ 1	2020-03-26 00:22:40	announced

Dataset with its publication pending

submitter keyword: hemisphere asymmetry, Parkinson’s disease, aging, enhancer, neurons, epigenetics

Viviane Labrie
contact affiliation	Van Andel Research Institute
contact email	viviane.labrie@vai.org
lab head
PEIPEI LI
contact affiliation	Van Andel Research Institute
contact email	lipeipei0611@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015239
     1. Label: PRIDE project
     2. Name: Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease