PXD015197

PXD015197 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics to uncover phosphorylation substrates changes when serine/threonine protein kinase PknA and PknB depletion
Description	The Mycobacterium tuberculosis eukaryotic-like serine/threonine protein kinase (STPKs) PknA and PknB regulate several processes required for cell growth, both kinase have been found to be and can be investigated by using the conditional mutant. In the present study, we created the M. tuberculosis kinase PknA/ PknB depletion mutant and performed the phosphoproteomics to uncover phosphorylation substrates changes when PknA/ PknB depletion.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:06:04.432.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Saima Ahmed
SpeciesList	scientific name: Mycobacterium tuberculosis C StG4006; NCBI TaxID: 1268634;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-28 07:08:18	ID requested
1	2020-05-26 16:53:53	announced
⏵ 2	2024-10-22 05:06:10	announced	2024-10-22: Updated project metadata.

10.1371/journal.ppat.1008452;

Zeng J, Platig J, Cheng TY, Ahmed S, Skaf Y, Potluri LP, Schwartz D, Steen H, Moody DB, Husson RN, Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility. PLoS Pathog, 16(4):e1008452(2020) [pubmed]

submitter keyword: Mycobacterium tuberculosis

serine/threonine protein kinase (STPKs) PknA and PknB

phosphoproteomics

Hanno Steen
contact affiliation	Boston Children's Hospital
contact email	hanno.steen@childrens.harvard.edu
lab head
Saima Ahmed
contact affiliation	Boston Children's Hospital
contact email	saima.ahmed@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD015197

PRIDE project URI

• PRIDE
  1. PXD015197
     1. Label: PRIDE project
     2. Name: Phosphoproteomics to uncover phosphorylation substrates changes when serine/threonine protein kinase PknA and PknB depletion