PXD015174

PXD015174 is an original dataset announced via ProteomeXchange.

Title	Lysine acetylation of the housekeeping sigma factor enhances the activity of RNA polymerase holoenzyme
Description	Protein lysine acetylation is one of the abundant post-translational modifications in eukaryotes, but found in prokaryotes as well. Despite the evidence of the lysine acetylation in the prokaryotic RNA polymerases (RNAPs), its function remains unrevealed. We revealed that the housekeeping sigma factor (HrdB) was acetylated throughout the growth of Streptomyces venezuelae. The 259th lysine (K259) located between 1.2 and 2 regions was determined as the acetylated residue of HrdB in vivo by LC-MS/MS analyses
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_15:20:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ji-Eun Kim
SpeciesList	scientific name: Streptomyces venezuelae; NCBI TaxID: 54571;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-27 06:37:56	ID requested
⏵ 1	2020-05-26 15:20:34	announced

Kim JE, Choi JS, Kim JS, Cho YH, Roe JH, Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme. Nucleic Acids Res, 48(5):2401-2411(2020) [pubmed]

curator keyword: Biological

submitter keyword: RNA Polymerase, Sigma Factor, Lysine Acetylation, Transcription

Jung-Hye Roe
contact affiliation	Laboratory of Molecular Microbiology, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul 08826, Korea
contact email	jhroe@snu.ac.kr
lab head
Ji-Eun Kim
contact affiliation	Seoul National University
contact email	jieunii87@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD015174
     1. Label: PRIDE project
     2. Name: Lysine acetylation of the housekeeping sigma factor enhances the activity of RNA polymerase holoenzyme