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PXD015137

PXD015137 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlehnRNP M and HSP 90α as Potential Biomarkers in Early Stage Cutaneous Head and Neck Melanoma Tissue
DescriptionBackground: Timely diagnosis is important for successful treatment of cutaneous melanoma. Currently, Breslow tumor thickness and mitotic rate are used for malignant melanoma classification and prognosis, but these parameters can assess disease progression risk only to a certain degree. Therefore, there is a need for new melanoma protein biomarkers that would aid early and accurate diagnosis and prediction of their metastatic potential. Methodology and Findings: This retrospective case control study is based on proteomic profiling of formalin-fixed archival tissues of 31 early-stage head and neck cutaneous malignant melanoma samples using liquid chromatography / mass spectrometry. A melanoma proteomic profile was identified and protein expression levels were compared to the proteome profile of melanocytic naevi and correlated to established prognostic factors and disease-specific survival. In accordance with the American Joint Committee on Cancer guidelines, recursive partitioning multivariate analysis was used to identify potential biomarkers associated with metastatic potential of early-melanoma. Heterogeneous nuclear ribonucleoprotein M and heat shock protein 90 alpha were profiled as independent prognostic factors. Their elevated expression was clinically relevant for predicting an exceedingly high metastatic hazard ratio. These proteins were superior in estimating disease progression risk when compared to Breslow thickness and mitotic rate. Conclusions and Significance: Identification of biomarkers in early stage cutaneous head and neck melanoma is an important step towards predicting metastatic potential and prognosis of the disease. Clinical confirmation and further validation of the proteins identified in this study would provide a novel tool for identifying patients at risk for developing metastatic disease.
HostingRepositoryPRIDE
AnnounceDate2019-11-27
AnnouncementXMLSubmission_2020-01-14_07:39:29.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRuđer Novak
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Discovery
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-08-23 06:02:18ID requested
12019-11-27 04:29:49announced
22020-01-14 07:39:30announced2020-01-14: Updated publication reference for PubMed record(s): 31803364.
Publication List
Ko, š, ec A, Novak R, Konjevoda P, Trkulja V, Bedekovi, ć V, Grgurevi, ć L, as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study. Oncotarget, 10(62):6713-6722(2019) [pubmed]
Keyword List
submitter keyword: melanoma
early stage
proteomics
tissue
biomarkers
hnRNP M
HSP 90α
Contact List
Lovorka Grgurević
contact affiliationDepartment for Proteomics, Center for Translational and Clinical Research, School of Medicine, University of Zagreb Department of Anatomy “Drago Perović”, School of Medicine, University of Zagreb
contact emaillovorka.grgurevic@mef.hr
lab head
Ruđer Novak
contact affiliationSchool of Medicine, University of Zagreb
contact emailrudjer.novak@mef.hr
dataset submitter
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Dataset FTP location
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