PXD015137 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | hnRNP M and HSP 90α as Potential Biomarkers in Early Stage Cutaneous Head and Neck Melanoma Tissue |
Description | Background: Timely diagnosis is important for successful treatment of cutaneous melanoma. Currently, Breslow tumor thickness and mitotic rate are used for malignant melanoma classification and prognosis, but these parameters can assess disease progression risk only to a certain degree. Therefore, there is a need for new melanoma protein biomarkers that would aid early and accurate diagnosis and prediction of their metastatic potential. Methodology and Findings: This retrospective case control study is based on proteomic profiling of formalin-fixed archival tissues of 31 early-stage head and neck cutaneous malignant melanoma samples using liquid chromatography / mass spectrometry. A melanoma proteomic profile was identified and protein expression levels were compared to the proteome profile of melanocytic naevi and correlated to established prognostic factors and disease-specific survival. In accordance with the American Joint Committee on Cancer guidelines, recursive partitioning multivariate analysis was used to identify potential biomarkers associated with metastatic potential of early-melanoma. Heterogeneous nuclear ribonucleoprotein M and heat shock protein 90 alpha were profiled as independent prognostic factors. Their elevated expression was clinically relevant for predicting an exceedingly high metastatic hazard ratio. These proteins were superior in estimating disease progression risk when compared to Breslow thickness and mitotic rate. Conclusions and Significance: Identification of biomarkers in early stage cutaneous head and neck melanoma is an important step towards predicting metastatic potential and prognosis of the disease. Clinical confirmation and further validation of the proteins identified in this study would provide a novel tool for identifying patients at risk for developing metastatic disease. |
HostingRepository | PRIDE |
AnnounceDate | 2019-11-27 |
AnnouncementXML | Submission_2020-01-14_07:39:29.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ruđer Novak |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Discovery |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-08-23 06:02:18 | ID requested | |
1 | 2019-11-27 04:29:49 | announced | |
⏵ 2 | 2020-01-14 07:39:30 | announced | 2020-01-14: Updated publication reference for PubMed record(s): 31803364. |
Publication List
Ko, š, ec A, Novak R, Konjevoda P, Trkulja V, Bedekovi, ć V, Grgurevi, ć L, as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: A proteomics-based study. Oncotarget, 10(62):6713-6722(2019) [pubmed] |
Keyword List
submitter keyword: melanoma |
early stage |
proteomics |
tissue |
biomarkers |
hnRNP M |
HSP 90α |
Contact List
Lovorka Grgurević |
contact affiliation | Department for Proteomics, Center for Translational and Clinical Research, School of Medicine, University of Zagreb Department of Anatomy “Drago Perović”, School of Medicine, University of Zagreb |
contact email | lovorka.grgurevic@mef.hr |
lab head | |
Ruđer Novak |
contact affiliation | School of Medicine, University of Zagreb |
contact email | rudjer.novak@mef.hr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD015137 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD015137
- Label: PRIDE project
- Name: hnRNP M and HSP 90α as Potential Biomarkers in Early Stage Cutaneous Head and Neck Melanoma Tissue