PXD015136

PXD015136 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Dementia
Description	Background/Aims: The discovery of predictive biomarker for Alzheimer’s disease (AD) from urine would be highly beneficial for preventative approach of the disease, but the information about biological and pathophysiological changes observed in the molecular composition of urine of AD patient is limited. This study aimed to explore the comprehensive profile and molecular network relations of urinary proteins in the urine of AD patients. Methods: Urine samples collected from 18 AD patients and 18 age- and sex- matched cognitively normal controls were analyzed by mass spectrometry and semi-quantified by normalized spectral index method. Bioinformatics analyses were performed on the proteins which significantly increased more than two-fold or decreased less than 0.5-fold compared to the control (p< 0.05) using DAVID bioinformatics resources and KeyMolnet software. Results: 109 proteins were significantly increased or decreased in AD urine compared to control. Among those differentially expressed proteins, annotation clusters related to lysosome, complement activation, and gluconeogenesis were significantly enriched. The molecular relation network calculated from those proteins were mainly associated to pathways of lipoprotein metabolism, heat shock protein 90 signaling, matrix metalloproteinase signaling, and redox regulation by thioredoxin. Conclusion: The study suggested that the change of urinary proteome reflect the systemic change related to AD pathophysiology.
HostingRepository	jPOST
AnnounceDate	2019-08-23
AnnouncementXML	Submission_2022-09-18_02:40:21.082.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yoshitoshi Hirao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	unknown modification; S-carboxamidomethyl-L-cysteine
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-22 16:51:59	ID requested
1	2019-08-22 16:53:49	announced
2	2021-02-04 16:35:18	announced	2021-02-04: Updated FTP location.
⏵ 3	2022-09-18 02:40:21	announced	2022-09-18: Updated FTP location.

Keyword List

submitter keyword: urine, Alzheimer's disease, biomarker

submitter keyword: urine, Alzheimer's disease, biomarker

Contact List

Yumi Watanabe
lab head
Yoshitoshi Hirao
contact affiliation	Niigata University
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000475/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000475/