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PXD015045

PXD015045 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleShotgun proteomics of Roseburia grown on human milk oligosaccharides and of Roseburia grown on mucin in co-culture with Akkermansia muciniphilia.
DescriptionThe main objective of the present proteomic study is to identify the metabolic response, in particular theglycan uptake and degradation machinery, conferring members of Roseburia growth on HMOs and/or onrelated O-glycans. Accordingly, the proteomes of R. hominis and R. inulinivorans bothgrown on humanmilk oligosaccharides (HMOs), were compared to glucose to reveal the molecular basis for growth onHMOs. Furthermore, we compare the proteomes of R. hominis and R. inulinivorans grownin co-culturewith A. muciniphilia either on mucin or on glucose to identify potential metabolic routes of mucin derivedO-glycan utilization in Roseburia.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:08:28.395.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Pichler
SpeciesList scientific name: Akkermansia muciniphila ATCC BAA-835; NCBI TaxID: 349741; scientific name: Roseburia hominis A2-183; NCBI TaxID: 585394; scientific name: Roseburia inulinivorans DSM 16841; NCBI TaxID: 622312;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-08-16 01:10:11ID requested
12020-07-05 22:08:09announced
22024-10-22 05:08:33announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41467-020-17075-x;
Pichler MJ, Yamada C, Shuoker B, Alvarez-Silva C, Gotoh A, Leth ML, Schoof E, Katoh T, Sakanaka M, Katayama T, Jin C, Karlsson NG, Arumugam M, Fushinobu S, Abou Hachem M, Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways. Nat Commun, 11(1):3285(2020) [pubmed]
Keyword List
submitter keyword: LC-MSMS, Metaproteomics,Roseburia, Proteomics, HMOs, Mucin, Akkermansia muciniphilia, O-glycans
Contact List
Maher Abou Hachem
contact affiliationDTU BIOENGINEERING Department of Biotechnology and Biomedicine PCET-Protein Glycoscience and Biotechnology Technical University of Denmark 2800 Kgs. Lyngby
contact emailmaha@bio.dtu.dk
lab head
Michael Pichler
contact affiliationDTU
contact emailmijap@dtu.dk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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