PXD015000
PXD015000 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Differential Proteomic Analysis of Fetal and Geriatric Lumbar Nucleus Pulposus |
| Description | Intervertebral disc degeneration (IVDD) is a main cause of degenerative disc disease, which results in substantial pain among patients. However, the mechanism of degeneration remains unclear. Thus far, basic research on human IVDD has focused on only a limited number of proteins and has not been conducted from a holistic perspective. In this study, we used tandem mass tag (TMT) labeling combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to perform differential proteomic analysis on fetal and geriatric lumbar disc nucleus pulposus tissue. These data indicate that differential proteomics analysis may be an important method for elucidation of the pathophysiological process and molecular biological mechanism of human IVDD from a holistic perspective. The findings in this study will aid in screening of new biomarkers for early diagnosis and targeted treatment of IVDD. |
| HostingRepository | iProX |
| AnnounceDate | 2020-05-02 |
| AnnouncementXML | Submission_2020-11-30_00:19:40.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chensheng Qiu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive; Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-08-12 21:13:02 | ID requested | |
| 1 | 2020-05-01 20:21:49 | announced | |
| ⏵ 2 | 2020-11-30 00:19:41 | announced | 2020-11-30: Update publication information |
Publication List
| Qiu C, Wu X, Bian J, Ma X, Zhang G, Guo Z, Wang Y, Ci Y, Wang Q, Xiang H, Chen B, Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration. BMC Musculoskelet Disord, 21(1):339(2020) [pubmed] |
Keyword List
| submitter keyword: Intervertebral disc degeneration, proteomic analysis |
Contact List
| Bohua Chen | |
|---|---|
| contact affiliation | Affiliated Hospital of Qingdao University |
| contact email | bhchen@hotmail.com |
| lab head | |
| Chensheng Qiu | |
| contact affiliation | Qingdao University |
| contact email | qiuchensheng0510@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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