PXD014938

PXD014938 is an original dataset announced via ProteomeXchange.

Title	MKPV (aka MuCPV) and related chapparvoviruses are nephro-tropic and encode novel accessory proteins p15 and NS2.
Description	Mouse kidney parvovirus (MKPV) is a member of the provisional Chapparvovirus group that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four MKPV transcripts, created by alternative splicing, to a common transcription initiation region, and use mass spectrometry to identify “p10” and “p15” as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and a splicing dependent putative accessory protein NS2 are conserved in all near-complete tetrapod chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a primate chapparvovirus,CKPV, are also found in the kidneys of their hosts. We propose, therefore, that chapparvoviruses with >60% VP1 amino acid identity to MKPV be classified into a genus Nephro-tropic chapparvoviruses dubbed Nephroparvovirus, which is consistent with nomenclature for the genus Erythroparvovirus.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:50:08.455.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matthew Padula
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-08 01:41:07	ID requested
1	2020-01-06 01:57:21	announced
2	2020-01-06 01:58:49	announced	2020-01-06: Updated publication reference for DOI(s): 10.1371/journal.ppat.1008262.
⏵ 3	2023-11-14 08:50:08	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: mouse,chapparvovirus, LC-MS/MS

Christopher J Jolly
contact affiliation	Adult Cancer Program, Faculty of Medicine, Lowy Cancer Research Centre, University of New South Wales Sydney, NSW, Australia
contact email	c.jolly@unsw.edu.au
lab head
Matthew Padula
contact affiliation	University of technology Sydney
contact email	matthew.padula@uts.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD014938
     1. Label: PRIDE project
     2. Name: MKPV (aka MuCPV) and related chapparvoviruses are nephro-tropic and encode novel accessory proteins p15 and NS2.