Updated publication reference for PubMed record(s): 31533042. This project contains the raw and result files for a mass spectrometry analysis comparing the abundance of proteins following chromatin fractionation in growing cells and in senescent cells for the WI-38hTERT/GFP-RAF1-ER cell line. Two replicas were analysed for each cell condition. The data are used to support a study on using polymer modelling to investigate the roles of heterochromatin and lamina interactions on chromosome reorganisation in senescence.