PXD014919

PXD014919 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of a precision knock-out Glycogen Synthase Kinase 3B model identifies new roles for GSK3B in colorectal cancer
Description	Glycogen-specific kinase (GSK3β) is an integral regulator of the Wnt signalling pathway as well as many other diverse signalling pathways and processes. Dys-regulation of GSK3β is implicated in many different pathologies, including neurodegenerative disorders as well as many different tumour types. An important GSK3β mechanism of action is phosphorylation of substrates with consequent inhibition or degradation. In the context of tumour development, GSK3β has been shown to play both oncogenic and tumour suppressor roles, depending upon tissue, signalling environment or disease progression. Although multiple substrates of the GSK3β kinase have been identified, the wider protein networks within which protein-protein interaction networks and complexes within which GSK3β participates are not well known, and the consequences of these interactions not well understood. In this study LC-MS/MS expression analysis of knock-out GSK3β colorectal cancer cells is used as well as to understand the consequences on these interaction partners of GSK3β deletion from the system.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:29:43.198.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rob Ewing
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-05 08:15:05	ID requested
1	2021-10-07 08:28:10	announced
⏵ 2	2024-10-22 05:29:43	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: GSK3B

HCT116

colorectal cancer

Rob Ewing
contact affiliation	University of Southampton
contact email	rob.ewing@soton.ac.uk
lab head
Rob Ewing
contact affiliation	Univ Southampton
contact email	rob.ewing@soton.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/10/PXD014919

PRIDE project URI

• PRIDE
  1. PXD014919
     1. Label: PRIDE project
     2. Name: Proteomic analysis of a precision knock-out Glycogen Synthase Kinase 3B model identifies new roles for GSK3B in colorectal cancer