PXD014917

PXD014917 is an original dataset announced via ProteomeXchange.

Title	Personalized Human Milk Profiling
Description	Human milk is the truest form of personalized nutrition, supporting dynamic needs of the infant with important nutritional and bioactive constituents that change throughout lactation. Additionally, human milk is individual specific and is unique for each mother-infant dyad. Proteins and endogenous peptides are 2 key classes of major human milk components making up the proteome, each with unique and synergistic functionality, working to provide protection for the healthy development of infants. Our objective was to comprehensively characterize and quantify the human milk proteome for varying early life challenges. We assessed in-depth individual variations of the human milk proteome across lactation, by mass spectrometry. Finding that the human milk proteome showed continuous and gradual changes over lactation, and that inflammatory events correlated with a strong and rapid change in the composition of human milk proteins and peptides. Personalized human milk profiling resulted in the systematic annotation of the milk proteome, and elucidated how early onset inflammatory events can lead to infant immune training from human milk.
HostingRepository	PRIDE
AnnounceDate	2021-02-09
AnnouncementXML	Submission_2021-02-08_22:40:19.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD014917
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kelly Dingess
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Oxidation; Acetyl; Carbamidomethyl
Instrument	Orbitrap Fusion Lumos; Orbitrap Fusion; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-08-05 03:38:01	ID requested
⏵ 1	2021-02-08 22:40:19	announced

Dataset with its publication pending

submitter keyword: Endogenous Peptides, Human Milk, Immunity, Personalized Nutrition, Proteins

Albert J.R. Heck
contact affiliation	Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht Netherlands Proteomics Center
contact email	A.J.R.Heck@uu.nl
lab head
Kelly Dingess
contact affiliation	Utrecht University
contact email	k.a.dingess@uu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD014917

PRIDE project URI

• PRIDE
  1. PXD014917
     1. Label: PRIDE project
     2. Name: Personalized Human Milk Profiling