PXD014846

PXD014846 is an original dataset announced via ProteomeXchange.

Title	Vaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
Description	This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWATH-MS strategy were applied to profile changes in protein expression at early and middle stage of pregnancy. Using in-house generated HVF-specific protein library, 61 proteins (>1.5 fold at V2/V1 or V3/V1, q-value <0.05) changed as a function of gestational age. The stage-specific expression pattern of these proteins was mainly associated with the biology of cervical remolding, fetal development and microbial defense.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:18:27.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bhoj Kumar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-31 01:24:13	ID requested
1	2021-01-29 00:21:46	announced
⏵ 2	2024-10-22 05:18:27	announced	2024-10-22: Updated project metadata.

Kumar B, Dey AK, Saha S, Singh AK, Kshetrapal P, Wadhwa N, Thiruvengadam R, Desiraju BK, Bhatnagar S, Salunke DM, Rashid F, Malakar D, Maiti TK, Dynamic Alteration in the Vaginal Secretory Proteome across the Early and Mid-Trimesters of Pregnancy. J Proteome Res, 20(2):1190-1205(2021) [pubmed]

10.1021/acs.jproteome.0c00433;

submitter keyword: pregnancy, human vaginal fluid,Longitudinal study, SWATH MS

Tushar Kanti Maiti
contact affiliation	Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad 121001, INDIA.
contact email	tkmaiti@rcb.res.in
lab head
Bhoj Kumar
contact affiliation	Regional Centre for Biotechnology NCR Biotech Science Cluster 3rd Milestone, Faridabad-Gurgaon Expressway P.O. Box No. 3, Faridabad - 121 001 Haryana (NCR Delhi), India
contact email	bhoj.kumar@rcb.res.in
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/01/PXD014846

PRIDE project URI

• PRIDE
  1. PXD014846
     1. Label: PRIDE project
     2. Name: Vaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy