PXD014819 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemical inhibition of the target of rapamycin kinase in Chlamydomonas reinhardtii leads to rapid cysteine oxidation and sustained physiological changes. |
Description | The target of rapamycin (TOR) kinase is a key metabolic regulator with a role in diverse processes, including nutritional sensing, protein translation, and autophagy. In the green alga Chlamydomonas reinhardtii, TOR maintains these responsibilities and is additionally linked to the regulation of increased triacylglycerol accumulation. In this study, we used an ATP-competitive inhibitor (AZD8055) to inactivate TOR kinase in vivo and quantified any accompanying changes in global protein abundance and reversible cysteine oxidation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-07 |
AnnouncementXML | Submission_2024-10-07_10:30:03.986.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD014819 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Evan McConnell |
SpeciesList | scientific name: Chlamydomonas reinhardtii; NCBI TaxID: 3055; |
ModificationList | Oxidation; Acetyl |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-30 01:21:02 | ID requested | |
⏵ 1 | 2024-10-07 10:30:04 | announced | |
Publication List
Keyword List
submitter keyword: AZD8055, global proteomics,Chlamydomonas reinhardtii, target of rapamycin, reversible cysteine oxidation |
Contact List
Leslie M. Hicks |
contact affiliation | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA |
contact email | lmhicks@unc.edu |
lab head | |
Evan McConnell |
contact affiliation | Graduate Research Assistant |
contact email | evanmcc@live.unc.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD014819 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014819
- Label: PRIDE project
- Name: Chemical inhibition of the target of rapamycin kinase in Chlamydomonas reinhardtii leads to rapid cysteine oxidation and sustained physiological changes.