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PXD014817

PXD014817 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcription
DescriptionThe existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance. Here, we report that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression. Elevated TRIB3 expression supports BCSCs by interacting with AKT to interfere with the FOXO1-AKT interaction and suppress FOXO1 phosphorylation, ubiquitination, and degradation by E3 ligases SKP2 and NEDD4L. The accumulated FOXO1 promotes transcriptional expression of SOX2, a transcriptional factor for cancer stemness, which in turn, activates FOXO1 transcription and forms a positive regulatory loop. Disturbing the TRIB3-AKT interaction suppresses BCSCs by accelerating FOXO1 degradation and reducing SOX2 expression in mouse models of breast cancer. Our study provides insights into breast cancer development and confers a potential therapeutic strategy against TRIB3-overexpressed breast cancer.
HostingRepositoryiProX
AnnounceDate2019-07-30
AnnouncementXMLSubmission_2019-09-18_19:56:52.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJinmei Yu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-30 00:29:41ID requested
12019-09-18 19:56:53announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: FOXO1 Interacting protein
Contact List
Bing Cui
contact affiliationInstitute of Materia Medica
contact emailcuibing@imm.ac.cn
lab head
Jinmei Yu
contact affiliationInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
contact emailyujinmei198303@126.com
dataset submitter
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