PXD014770 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative analysis of in vivo methionine oxidation of the human proteome |
Description | A novel stable isotope labelling stategy was developed to quantify methionine oxidation in an unstressed human proteome. Cell extracts were oxidized with 18O labelled hydrogen peroxide following cell lysis in order to convert all unoxidized methionine residues to an oxidized version with a heavy label. The heavy labelled peptides were used to generate a custom search and quantification of the relative ratios between heavy and light labelled methionine sulfoxide containing peptides. Where the light labelled peptides were in vivo oxidized |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-26 |
AnnouncementXML | Submission_2019-07-26_07:51:18.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | John Bettinger |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-26 02:27:58 | ID requested | |
⏵ 1 | 2019-07-26 07:51:19 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: methionine oxidation, human cell line, unstressed proteome |
Contact List
Sina Ghaemmaghami |
contact affiliation | University of Rochester Biology Department |
contact email | sina.ghaemmaghami@rochester.edu |
lab head | |
John Bettinger |
contact affiliation | University of Rochester |
contact email | jbetting@ur.rochester.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014770
- Label: PRIDE project
- Name: Quantitative analysis of in vivo methionine oxidation of the human proteome