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PXD014751

PXD014751 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative proteomics of liver and plasma on the CDAA rat NASH model
DescriptionNonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be useful for drug development. To identify new plasma biomarkers in a choline-deficient L-amino acid-defined diet rat NASH model we analyzed liver and plasma samples by proteomics, revealing disease relevant signatures and a high correlation between liver mRNA and protein changes. We developed a multi-dimensional attribute ranking approach integrating multi-omics data with liver histology and prior knowledge uncovering known human markers, but also novel candidates. Using regression analysis, we show that the top-ranked plasma markers were highly predictive for fibrosis in our model and hence can serve as preclinical plasma biomarkers. Our approach presented here illustrates the power of multi-omics analyses combined with plasma proteomics and is readily applicable to human biomarker discovery.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:58:40.649.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDaniel Veyel
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-25 01:57:03ID requested
12020-01-28 04:36:31announced
22020-02-04 02:28:03announced2020-02-04: Updated publication reference for PubMed record(s): 31992752.
32020-02-17 03:22:41announced2020-02-04: Updated publication reference for PubMed record(s): 31992752.
2020-02-17: Updated publication reference for PubMed record(s): 31992752.
42024-10-22 04:58:47announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41598-020-58030-6;
Veyel D, Wenger K, Broermann A, Bretschneider T, Luippold AH, Krawczyk B, Rist W, Simon E, Biomarker discovery for chronic liver diseases by multi-omics - a preclinical case study. Sci Rep, 10(1):1314(2020) [pubmed]
Keyword List
submitter keyword: LC-MSMS, Plasma,Han Wistar rat, Liver
Contact List
Wolfgang Rist
contact affiliationBoehringer Ingelheim Pharma GmbH & Co. KG, Drug Discovery Sciences
contact emailwolfgang.rist@boehringer-ingelheim.com
lab head
Daniel Veyel
contact affiliationBoehringer Ingelheim Pharma GmbH & Co. KG
contact emaildaniel.veyel@boehringer-ingelheim.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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