PXD014747

PXD014747 is an original dataset announced via ProteomeXchange.

Title	Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection
Description	Emerging evidence indicates that viral infection alters protein complex composition to induce both proviral and antiviral effects. However, global changes in protein complexes during infection remains understudied. Here, we employ thermal proximity coaggregation (TPCA) analysis to provide the first global and temporal characterization of changes in protein complexes during human cytomegalovirus (HCMV) infection. This dataset provides a resource to mine the alterations in protein complexes during HCMV infection. Furthermore, our subsequent experiments identified that these changes in protein complex composition and interactions functionally contribute to the progression of infection.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:57:50.697.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yutaka Hashimoto
SpeciesList	scientific name: Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5); NCBI TaxID: 10360; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-25 01:39:32	ID requested
1	2020-01-29 13:02:54	announced
2	2020-03-24 01:10:36	announced	2020-03-24: Updated publication reference for PubMed record(s): 32041945.
⏵ 3	2024-10-22 04:57:52	announced	2024-10-22: Updated project metadata.

Hashimoto Y, Sheng X, Murray-Nerger LA, Cristea IM, Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection. Nat Commun, 11(1):806(2020) [pubmed]

10.1038/s41467-020-14586-5;

submitter keyword: TPCA, MS-CETSA, cellular thermal shift assay, herpesvirus, thermal proximity coaggregation,HCMV, cytomegalovirus

Ileana M. Cristea
contact affiliation	Department of Molecular Biology, Princeton University
contact email	icristea@princeton.edu
lab head
Yutaka Hashimoto
contact affiliation	Princeton University
contact email	yutakah@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD014747

PRIDE project URI

• PRIDE
  1. PXD014747
     1. Label: PRIDE project
     2. Name: Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection