PXD014709

PXD014709 is an original dataset announced via ProteomeXchange.

Title	Pharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
Description	We analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to single ER stress, several important plasma-membrane associated kinases, showed a significant downregulation under PERK inhibition.
HostingRepository	PRIDE
AnnounceDate	2020-03-02
AnnouncementXML	Submission_2020-04-22_03:14:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christian Preisinger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	biotinylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-23 05:48:25	ID requested
1	2020-03-02 05:48:23	announced
⏵ 2	2020-04-22 03:14:08	announced	2020-04-22: Updated publication reference for PubMed record(s): 32161259.

Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, Preisinger C, Wilhelm T, Huber M, Tirosh B, Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun, 11(1):1304(2020) [pubmed]

submitter keyword: human, LC-MS, plasma membrane

Boaz Tirosh
contact affiliation	The School of Pharmacy The Hebrew University of Jerusalem POB 12065 Jerusalem 9112002, Israel
contact email	boazt@ekmd.huji.ac.il
lab head
Christian Preisinger
contact affiliation	Proteomics Facility, IZKF Aachen, University Clinic RWTH Aachen
contact email	cpreisinger@ukaachen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD014709

PRIDE project URI

• PRIDE
  1. PXD014709
     1. Label: PRIDE project
     2. Name: Pharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy