PXD014705

PXD014705 is an original dataset announced via ProteomeXchange.

Title	GlycoNote search engine
Description	Mass spectrometry is a central technique in glycomic analysis. However, there is no generic software tool for automated, confident analysis of tandem-mass spectrometry based glycomic data. Here, we propose GlycoNote – a generic and reliable search engine for tandem-mass spectrometry based glycomics. A false discovery rate analysis based on iterative decoy searching was specifically designed for glycomic data analysis. We apply GlycoNote to the analyses of distinct glycomic samples, including human milk oligosaccharides, N/O-glycome from human cell line and polysaccharides from plant. To further demonstrate the general utility of GlycoNote, automated analyses of nonnative glycomes (N-glycome labeled with aniline and permethylated N-glycome) or atypical glycans (O-glycome with N-acetylneuraminic acid / N-glycome from C. elegans) were performed. More importantly, an open-search mode was introduced for the elucidation of component heterogeneity in samples. GlycoNote could be an important tool in the rapidly growing efforts toward comprehensive glycomic analysis.
HostingRepository	iProX
AnnounceDate	2019-07-23
AnnouncementXML	Submission_2019-07-23_02:57:57.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mingqi Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-23 02:55:48	ID requested
⏵ 1	2019-07-23 02:57:58	announced

Dataset with its publication pending

submitter keyword: Glycomics, Glycoproteoimcs

Yuanyang Peng
contact affiliation	Fudan Univerisity
contact email	pyyang@fudan.edu.cn
lab head
Mingqi Liu
contact affiliation	Institutes of biomedical Sciences, Fudan University
contact email	mingqiliu10@icloud.com
dataset submitter

iProX dataset URI