PXD014702
PXD014702 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | immuno-MRM analysis of a 4 protein based classifier predicting outcome to tamoxifen resistance, TSQ (De Marchi, et al. 2106) |
| Description | We selected a total of 47 breast cancer tissues which displayed at least (≥) 50% tumor area from patients that manifested either good or poor outcome to tamoxifen treatment, which was defined as whether patients manifested disease progression before (≤; poor) or after (>; good) 6 months. This subset comprised 28 and 19 patients who manifested good and poor outcome, respectively (Table 1). An independent set of 26 breast cancer patient derived sera was selected as verification cohort. Sera were collected both prior start of first line tamoxifen therapy (Supplemental Table 1), and comprised 14 good and 12 poor outcome patients. Both cohorts were analyzed in singlicate as biological replicates. In order to assess the efficacy of immuno-capture coupled to MRM MS, a set of 8 ER positive tumor specimens (≥ 50% tumor area) was analyzed in two triplicated series (i.e. 8 x 3 replicates by standard MRM, 8 x 3 replicates by iMRM). |
| HostingRepository | PeptideAtlas |
| AnnounceDate | 2019-07-22 |
| AnnouncementXML | Submission_2019-07-22_11:07:45.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Tommaso De Marchi |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Xevo TQ-S; 4000 QTRAP |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-07-22 10:11:08 | ID requested | |
| ⏵ 1 | 2019-07-22 11:07:46 | announced |
Publication List
| De Marchi T, Kuhn E, Dekker LJ, Stingl C, Braakman RB, Opdam M, Linn SC, Sweep FC, Span PN, Luider TM, Foekens JA, Martens JW, Carr SA, Umar A, Targeted MS Assay Predicting Tamoxifen Resistance in Estrogen-Receptor-Positive Breast Cancer Tissues and Sera. J Proteome Res, 15(4):1230-42(2016) [pubmed] |
Keyword List
| curator keyword: selected reaction monitoring, SRM, targeted |
Contact List
| Tommaso De Marchi | |
|---|---|
| contact affiliation | Erasmus MC |
| contact email | t.demarchi@erasmusmc.nl |
| dataset submitter | |
| Arzu Umar | |
| contact affiliation | Erasmus University Medical Center |
| contact email | a.umar@erasmusmc.nl |
| lab head | |
Full Dataset Link List
| PeptideAtlas dataset URI |
| PASSEL transition group browser URI |
| PASSEL transition group browser URI |
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