PXD014672

PXD014672 is an original dataset announced via ProteomeXchange.

Title	Paracrine Signaling in Visceral Fat
Description	Accumulation of visceral (VIS) as opposed to subcutaneous (SUB) fat is a predictor of metabolic disorders, insulin resistance, and cardiovascular disease. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues, thus impairing insulin action. In addition, VIS adipose tissue is more prone to fibrosis and inflammation, which in turn contributes to the pathogenesis of metabolic disease. Mechanisms underlying selective hypertrophic growth and tissue remodeling properties of VIS fat are not well understood. We and others identified subsets of adipose progenitors (APs) unique to VIS fat with differential adipogenic capacity. We named these CD34+ APs VIS low and VIS high based on low or high CD34 expression respectively. Despite sharing the same developmental origin, VIS low APs are adipogenic whereas VIS high APs are not. Furthermore, VIS high APs inhibit adipogenic differentiation of SUB and VIS low APs in vitro through the secretion of soluble inhibitory factor(s) including insulin-like growth factor binding protein 2 (Igfbp2). The number of VIS high APs increased with VIS adipose tissue expansion and their abundance in vivo causes hypertrophic growth, fibrosis, inflammation and impaired glucose and insulin tolerance. This study unveil the presence of APs unique to VIS fat involved in the paracrine regulation of adipogenesis and tissue remodeling.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:40:09.912.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anna Bakhtina
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-19 01:47:26	ID requested
1	2024-05-21 09:21:15	announced
⏵ 2	2024-10-22 06:40:17	announced	2024-10-22: Updated project metadata.

Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S, Progenitors to the Regulation of Visceral Fat Expansion and Remodeling. Cell Rep, 29(2):270-282.e5(2019) [pubmed]

10.1016/j.celrep.2019.08.092;

submitter keyword: paracrine signaling,Mouse, visceral fat

Sarah Franklin
contact affiliation	Department of Internal Medicine – Cardiology Division Investigator, Nora Eccles Harrison Cardiovascular Research& Training Institute, University of Utah, Salt Lake City, UT, USA
contact email	sarah.franklin@utah.edu
lab head
Anna Bakhtina
contact affiliation	University of Washington
contact email	anna.bakhtina91@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD014672

PRIDE project URI

• PRIDE
  1. PXD014672
     1. Label: PRIDE project
     2. Name: Paracrine Signaling in Visceral Fat