PXD014664

PXD014664 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of septic renal acute phase response
Description	Sepsis-induced acute kidney injury (AKI) is the most common form of AKI with poor outcomes. Renal proteomic analysis after bacterial lipopolysaccharide (LPS) administration revealed that the local renal acute phase reaction (APR) is one of the strongest responses of the kidney during septic AKI in mice. Evaluation of mRNA expression confirmed that most acute phase proteins were produced in the kidney. Our study also provides missing information on the time course of septic renal APR. Proteomic analysis of LPS-induced AKI demonstrated a marked upregulation of local renal acute phase response (APR) that commenced a few hours post injection and peaked at 24 h. Much more APPs were involved in the renal APR than previously identified.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_03:59:07.277.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marko Fonovic
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-18 05:44:08	ID requested
1	2020-01-08 04:24:58	announced
⏵ 2	2024-10-22 03:59:15	announced	2024-10-22: Updated project metadata.

R, ó, ka B, Tod P, Kaucs, á, r T, Vizovi, š, ek M, Vidmar R, Turk B, Fonovi, ć M, Sz, é, n, á, si G, Hamar P, The Acute Phase Response Is a Prominent Renal Proteome Change in Sepsis in Mice. Int J Mol Sci, 21(1):(2019) [pubmed]

10.3390/ijms21010200;

submitter keyword: lipopolysaccharide,mouse, sepsis, kidney, LC-MS/MS

Marko Fonovic
contact affiliation	Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia
contact email	marko.fonovic@ijs.si
lab head
Marko Fonovic
contact affiliation	Jozef Stefan Institute
contact email	marko.fonovic@ijs.si
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD014664

PRIDE project URI

• PRIDE
  1. PXD014664
     1. Label: PRIDE project
     2. Name: Proteomic analysis of septic renal acute phase response