PXD014636

PXD014636 is an original dataset announced via ProteomeXchange.

Title	GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex
Description	ZEILUPE (ZTL), a blue light photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day light conditions to the circadian clock. To function properly, ZTL protein must accumulate but not destablilize target clock transcription factors before dusk, while in the dark ZTL mediates degradation of target proteins. It is not clear how ZTL can accumulate to high levels in the ligh while its targets remain stable. Two deubiquitylating enzymes, UBIQUITIN-SPECIFIC PROTEASE 12 and UBIQUITIN-SPECIFIC PROTEASE 13 (UBP12 and UBP13), which regulate colock period and protein ubiquitylation in a manner opposite to ZTL, were shown to associate with the ZTL protein complex. Here we demonstrate that the ZTL light-dependent interacting partner GIGANTEA (GI), recruites UBP12 and UBP13 to the ZTL photoreceptor complex.
HostingRepository	PRIDE
AnnounceDate	2019-08-22
AnnouncementXML	Submission_2019-08-30_00:42:17.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Man Wah Li
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-16 07:54:00	ID requested
1	2019-08-22 03:22:41	announced
⏵ 2	2019-08-30 00:42:18	announced	Updated publication reference for PubMed record(s): 31434902.

Lee CM, Li MW, Feke A, Liu W, Saffer AM, Gendron JM, GIGANTEA recruits the UBP12 and UBP13 deubiquitylases to regulate accumulation of the ZTL photoreceptor complex. Nat Commun, 10(1):3750(2019) [pubmed]

submitter keyword: Arabidopsis, GIGANTEA, UBP, ZEITLUPE, Circadian Clock, Deubiquitylases

Joshua M Gendron
contact affiliation	Yale University
contact email	joshua.gendron@yale.edu
lab head
Man Wah Li
contact affiliation	Yale University
contact email	limanwah@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD014636

PRIDE project URI

• PRIDE
  1. PXD014636
     1. Label: PRIDE project
     2. Name: GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex