PXD014619 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth |
Description | Preterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) before and after preterm birth. Using preterm pigs as model for preterm infants, we hypothesized that CA induces fetal and neonatal renal dysfunctions that can intially be detected via plasma proteome, partly explaining the frequent renal dysfunction in preterm infants. Fetal pigs (88% gestation) were given an IA dose of lipopolysaccharide (LPS, 1 mg/kg, n=28), delivered preterm by cesarean section three days later, and compared with controls (CON, n=26) at birth and postnatal day five. Plasma proteome and protein markers of inflammatory pathways were evaluated. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:20:26.258.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Allan Stensballe |
SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Bruker BAF format |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-15 06:34:15 | ID requested | |
1 | 2021-03-25 03:09:18 | announced | |
2 | 2021-03-25 05:27:49 | announced | 2021-03-25: Updated project metadata. |
⏵ 3 | 2024-10-22 05:20:27 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1016/j.ajpath.2018.07.020; |
Nguyen DN, Thymann T, Goericke-Pesch SK, Ren S, Wei W, Skovgaard K, Damborg P, Brunse A, van Gorp C, Kramer BW, Wolfs TG, Sangild PT, Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs. Am J Pathol, 188(11):2629-2643(2018) [pubmed] |
Keyword List
submitter keyword: Gram-negative infection, proteomics, chorioamnionitis, intrauterine bacterial infection, acute kidney injury |
Contact List
Laboratory for Medical Mass spectrometry |
contact affiliation | Laboratory for Medical mass spectrometry Aalborg University Fredrik bajersvej 3B; 9220 Aalborg Denmark |
contact email | as@hst.aau.dk |
lab head | |
Allan Stensballe |
contact affiliation | Aalborg University |
contact email | as@hst.aau.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014619
- Label: PRIDE project
- Name: Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth