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PXD014619

PXD014619 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleData in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth
DescriptionPreterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) before and after preterm birth. Using preterm pigs as model for preterm infants, we hypothesized that CA induces fetal and neonatal renal dysfunctions that can intially be detected via plasma proteome, partly explaining the frequent renal dysfunction in preterm infants. Fetal pigs (88% gestation) were given an IA dose of lipopolysaccharide (LPS, 1 mg/kg, n=28), delivered preterm by cesarean section three days later, and compared with controls (CON, n=26) at birth and postnatal day five. Plasma proteome and protein markers of inflammatory pathways were evaluated.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:20:26.258.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAllan Stensballe
SpeciesList scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationListiodoacetamide derivatized residue
InstrumentBruker BAF format
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-15 06:34:15ID requested
12021-03-25 03:09:18announced
22021-03-25 05:27:49announced2021-03-25: Updated project metadata.
32024-10-22 05:20:27announced2024-10-22: Updated project metadata.
Publication List
10.1016/j.ajpath.2018.07.020;
Nguyen DN, Thymann T, Goericke-Pesch SK, Ren S, Wei W, Skovgaard K, Damborg P, Brunse A, van Gorp C, Kramer BW, Wolfs TG, Sangild PT, Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs. Am J Pathol, 188(11):2629-2643(2018) [pubmed]
Keyword List
submitter keyword: Gram-negative infection, proteomics, chorioamnionitis, intrauterine bacterial infection, acute kidney injury
Contact List
Laboratory for Medical Mass spectrometry
contact affiliationLaboratory for Medical mass spectrometry Aalborg University Fredrik bajersvej 3B; 9220 Aalborg Denmark
contact emailas@hst.aau.dk
lab head
Allan Stensballe
contact affiliationAalborg University
contact emailas@hst.aau.dk
dataset submitter
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Dataset FTP location
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