PXD014619

PXD014619 is an original dataset announced via ProteomeXchange.

Title	Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth
Description	Preterm birth is often predisposed by chorioamnionitis (CA) and CA affects the fetal gut and lungs via intra-amniotic (IA) inflammation, thus accentuating the proinflammatory effects of preterm birth. It is not known if IA inflammation also affects other perfusion-sensitive organs (e.g., kidneys) before and after preterm birth. Using preterm pigs as model for preterm infants, we hypothesized that CA induces fetal and neonatal renal dysfunctions that can intially be detected via plasma proteome, partly explaining the frequent renal dysfunction in preterm infants. Fetal pigs (88% gestation) were given an IA dose of lipopolysaccharide (LPS, 1 mg/kg, n=28), delivered preterm by cesarean section three days later, and compared with controls (CON, n=26) at birth and postnatal day five. Plasma proteome and protein markers of inflammatory pathways were evaluated.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:20:26.258.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Allan Stensballe
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Bruker BAF format

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-15 06:34:15	ID requested
1	2021-03-25 03:09:18	announced
2	2021-03-25 05:27:49	announced	2021-03-25: Updated project metadata.
⏵ 3	2024-10-22 05:20:27	announced	2024-10-22: Updated project metadata.

10.1016/j.ajpath.2018.07.020;

Nguyen DN, Thymann T, Goericke-Pesch SK, Ren S, Wei W, Skovgaard K, Damborg P, Brunse A, van Gorp C, Kramer BW, Wolfs TG, Sangild PT, Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs. Am J Pathol, 188(11):2629-2643(2018) [pubmed]

submitter keyword: Gram-negative infection, proteomics, chorioamnionitis, intrauterine bacterial infection, acute kidney injury

Laboratory for Medical Mass spectrometry
contact affiliation	Laboratory for Medical mass spectrometry Aalborg University Fredrik bajersvej 3B; 9220 Aalborg Denmark
contact email	as@hst.aau.dk
lab head
Allan Stensballe
contact affiliation	Aalborg University
contact email	as@hst.aau.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD014619
     1. Label: PRIDE project
     2. Name: Data in support of Prenatal intra-amniotic lipopolysaccharide induces neonatal renal immune activation after preterm birth