PXD014606

PXD014606 is an original dataset announced via ProteomeXchange.

Title	Glioma Proteome explored by LC/MS/MS
Description	Gliomas are the most frequent and aggressive malignancies of the central nervous system. Gliomas accumulate genetic alterations that cilminate in enhanced activity of receptor tyrosine kinasesand downstream mediators. The genetic alterations (gene amplification/loss) are well characterised, little information is available regarding the changes in the proteome of gliomas of different grades. Therefore, an unbiased quantitative proteomics approach of human gliomas has been undertaken. The proteomics results indicate various up- and downregulation of pathways, in particular downregulation of the endocytic machinery components involved in initiation, formation, and scission of endocytic carriers. Both clathrin-dependent and -independent endocytosis were changed. The reduction of endocytic machinery components causes increased receptor cell surface levels, a prominent phenotype of defective endocytosis. The impaired endocytosis creates a selective advantage in glioma tumour progression due to prolonged receptor tyrosine signalling from the cell surface.
HostingRepository	PRIDE
AnnounceDate	2019-11-01
AnnouncementXML	Submission_2019-11-01_08:10:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paul Jenö
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-14 23:52:00	ID requested
1	2019-07-24 03:19:03	announced
⏵ 2	2019-11-01 08:10:17	announced	2019-11-01: Updated publication reference for PubMed record(s): 31331834.

Buser DP, Ritz MF, Moes S, Tostado C, Frank S, Spiess M, Mariani L, Jen, ö P, Boulay JL, Hutter G, Quantitative proteomics reveals reduction of endocytic machinery components in gliomas. EBioMedicine, 46():32-41(2019) [pubmed]

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: Glioma, Glioblastoma, Cancer, Endocytosis, Brain, Human

Paul Jenoe
contact affiliation	Biozentrum of the University of Basel
contact email	p.jenoe@bluewin.ch
lab head
Paul Jenö
contact affiliation	Biozentrum of the University of Basel, Switzerland
contact email	p.jenoe@bluewin.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD014606

PRIDE project URI

• PRIDE
  1. PXD014606
     1. Label: PRIDE project
     2. Name: Glioma Proteome explored by LC/MS/MS