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PXD014438

PXD014438 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNovel Protein Pathways in Development and Progression of Pulmonary Sarcoidosis.
DescriptionSarcoidosis is a disease that affects multiple organ systems, with lung disease seen commonly and is the most frequent cause of sarcoidosis-related mortality. We investigated to compare protein expression in the lung from both bronchoalveolar lavage fluid (BAL) cells and fluid (BALF) in newly diagnosed patients with sarcoidosis. Mass spectral data acquisition was conducted on an Orbitrap Fusion instrument in data-dependent mode using either label-free (BALF) or label-based (intracellular) approach. We identified 4,306 high confidence intracellular proteins (probability >99%) with 272 differentially expressed proteins controlling for an FDR  5%. The protein map to several known canonical pathways including phagosome maturation, clathrin-mediated endocytic signaling, NRF-2 mediated oxidant stress response, The examination of BALF identified 1,192 proteins, xxx and xxx protein with differential expression between controls vs. sarcoidosis and progressive vs. non-progressive sarcoidosis respectively. Several of the proteins identified mapping to the differentially expressed proteins were also detected in the BALF.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:26:14.755.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKevin Viken
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-07-01 01:39:51ID requested
12021-09-08 11:09:58announced
22024-10-22 05:26:15announced2024-10-22: Updated project metadata.
Publication List
Bhargava M, Viken KJ, Barkes B, Griffin TJ, Gillespie M, Jagtap PD, Sajulga R, Peterson EJ, Dincer HE, Li L, Restrepo CI, O'Connor BP, Fingerlin TE, Perlman DM, Maier LA, Novel protein pathways in development and progression of pulmonary sarcoidosis. Sci Rep, 10(1):13282(2020) [pubmed]
10.1038/s41598-020-69281-8;
Keyword List
submitter keyword: Sarcoidosis proteomics protein networks novel mechanism biomarkers BALF intracellular proteins
Contact List
Maneesh Bhargava
contact affiliationUniversity of Minnesota, Medical School, Associate Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
contact emailbharg005@umn.edu
lab head
Kevin Viken
contact affiliationUniversity of Minnesota
contact emailkviken@umn.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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