PXD014438 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Novel Protein Pathways in Development and Progression of Pulmonary Sarcoidosis. |
Description | Sarcoidosis is a disease that affects multiple organ systems, with lung disease seen commonly and is the most frequent cause of sarcoidosis-related mortality. We investigated to compare protein expression in the lung from both bronchoalveolar lavage fluid (BAL) cells and fluid (BALF) in newly diagnosed patients with sarcoidosis. Mass spectral data acquisition was conducted on an Orbitrap Fusion instrument in data-dependent mode using either label-free (BALF) or label-based (intracellular) approach. We identified 4,306 high confidence intracellular proteins (probability >99%) with 272 differentially expressed proteins controlling for an FDR 5%. The protein map to several known canonical pathways including phagosome maturation, clathrin-mediated endocytic signaling, NRF-2 mediated oxidant stress response, The examination of BALF identified 1,192 proteins, xxx and xxx protein with differential expression between controls vs. sarcoidosis and progressive vs. non-progressive sarcoidosis respectively. Several of the proteins identified mapping to the differentially expressed proteins were also detected in the BALF. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:26:14.755.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kevin Viken |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-07-01 01:39:51 | ID requested | |
1 | 2021-09-08 11:09:58 | announced | |
⏵ 2 | 2024-10-22 05:26:15 | announced | 2024-10-22: Updated project metadata. |
Publication List
Bhargava M, Viken KJ, Barkes B, Griffin TJ, Gillespie M, Jagtap PD, Sajulga R, Peterson EJ, Dincer HE, Li L, Restrepo CI, O'Connor BP, Fingerlin TE, Perlman DM, Maier LA, Novel protein pathways in development and progression of pulmonary sarcoidosis. Sci Rep, 10(1):13282(2020) [pubmed] |
10.1038/s41598-020-69281-8; |
Keyword List
submitter keyword: Sarcoidosis proteomics protein networks novel mechanism biomarkers BALF intracellular proteins |
Contact List
Maneesh Bhargava |
contact affiliation | University of Minnesota, Medical School, Associate Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine |
contact email | bharg005@umn.edu |
lab head | |
Kevin Viken |
contact affiliation | University of Minnesota |
contact email | kviken@umn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014438
- Label: PRIDE project
- Name: Novel Protein Pathways in Development and Progression of Pulmonary Sarcoidosis.