PXD014430

PXD014430 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis identified key proteins in association with hepatic metastatic colorectal cancer
Description	Purpose: Identification key proteins associated with colorectal cancer (CRC) development could help understand the mechanism and provide a way for the treatment of CRC at present and diagnosis. Experiment design: Weighted correlation network analysis (WGCNA) was used to analyze the proteomic data. Functional annotation and protein-protein interaction (PPI) network were used to seek key proteins. Finally, some of the key proteins were validated. Results: By functional annotation, the neutrophil-mediated immunity and metabolic pathway were the main function effected by CRC. In addition, hepatic metastatic CRC was concentrated in cell adhesion-related biological process. Through the PPI network, nine potentially critical targets (HSPD1, EEF1G, HNRNPA2B1, FGB, TLN1, AP2A2, SRRT, APOC3, PGM5) related to stage III and hepatic metastatic CRC were identified. Moreover, we confirmed that HSPD1 and FGB were involved in the development of CRC. Conclusion and clinical relevance: In summary, neutrophil-mediated immunity and the metabolic pathway are crucial in the development of CRC. We have identified potentially critical targets for stage III and hepatic metastatic CRC. HSPD1 acted as a biomarker, while FGB participated in hepatic metastatic CRC.
HostingRepository	iProX
AnnounceDate	2019-07-01
AnnouncementXML	Submission_2019-12-09_23:46:01.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ning Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600+

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-30 22:49:00	ID requested
1	2019-06-30 22:52:20	announced
⏵ 2	2019-12-09 23:46:02	announced	2019-12-10: Update publication information.

Yang W, Shi J, Zhou Y, Liu T, Li J, Hong F, Zhang K, Liu N, Co-expression Network Analysis Identified Key Proteins in Association With Hepatic Metastatic Colorectal Cancer. Proteomics Clin Appl, 13(6):e1900017(2019) [pubmed]

submitter keyword: CRC, Metastasis, proteomics, Label-free

Ning Liu
contact affiliation	Jilin University
contact email	liu_ning@jlu.edu.cn
lab head
Ning Liu
contact affiliation	Jilin University
contact email	liu_ning@jlu.edu.cn
dataset submitter

iProX dataset URI