PXD014423 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | COPZ1 depletion in thyroid tumor cells triggers type-I IFN response and immunogenic cell death |
Description | Thyroid carcinoma (TC) is generally associated with good prognosis, nevertheless no effective treatments are available for aggressive forms not cured by current therapies. We previously identified the coatomer protein complex zeta 1 (COPZ1), as a new putative therapeutic target for TC, since its depletion impairs the viability of tumor cells, leads to abortive autophagy, ER stress, unfolded protein response and apoptosis, and reduces the tumor growth of TC xenograft models. In this study, by combining genomic, proteomic and functional approaches, we provided evidence that COPZ1 silencing stimulates a type I IFN-mediated viral mimicry response, boosts the production of several inflammatory molecules and finally induces immunogenic cell death, which, in turn, promotes dendritic cell maturation and subsequent activation of T cells. Collectively, our findings support the notion that COPZ1 targeting can be exploited as a new strategy to kill cancer cells with the subsequent involvement of an anti-tumor immune response. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:05:47.520.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | gabriella tedeschi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-06-28 02:47:03 | ID requested | |
1 | 2020-03-05 08:32:13 | announced | |
⏵ 2 | 2024-10-22 04:05:55 | announced | 2024-10-22: Updated project metadata. |
Publication List
Di Marco T, Bianchi F, Sfondrini L, Todoerti K, Bongarzone I, Maffioli EM, Tedeschi G, Mazzoni M, Pagliardini S, Pellegrini S, Neri A, Anania MC, Greco A, COPZ1 depletion in thyroid tumor cells triggers type I IFN response and immunogenic cell death. Cancer Lett, 476():106-119(2020) [pubmed] |
10.1016/j.canlet.2020.02.011; |
Keyword List
submitter keyword: proteomics |
nano lc-ms-ms |
tumor; |
Contact List
Gabriella Tedeschi |
contact affiliation | università degli studi di Milano, medicina veterinaria, DIMEVET |
contact email | gabriella.tedeschi@unimi.it |
lab head | |
gabriella tedeschi |
contact affiliation | University of Milano |
contact email | gabriella.tedeschi@unimi.it |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD014423
- Label: PRIDE project
- Name: COPZ1 depletion in thyroid tumor cells triggers type-I IFN response and immunogenic cell death