PXD014413

PXD014413 is an original dataset announced via ProteomeXchange.

Title	Proteomics survey of Streptomyces coelicolor strains with natural gross chromosome change
Description	Streptomyces coelicolor normally produce spores with a relatively high heterogeneity, which will produce genetically heterogeneous sub-populations. These sub-populations often exert massive chromosome amplifications and deletions. Cells with gross chromosomal changes produce an increased diversity of secondary metabolites and secrete significantly more antibiotics; however, these changes come at the cost of dramatically reduced individual fitness, providing direct evidence for a trade-off between secondary metabolite production and fitness. We propose that antibiotic production in colonies of the multicellular bacterium Streptomyces coelicolor is coordinated by a division of labour. This proteomics survey will provide more detailed insights into how these chromosomal changed strains behave under normal growth condition.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_14:34:31.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD014413
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chao DU
SpeciesList	scientific name: Streptomyces coelicolor; NCBI TaxID: 1902;
ModificationList	Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-27 08:32:07	ID requested
⏵ 1	2020-05-26 14:34:32	announced

Zhang Z, Du C, de Barsy F, Liem M, Liakopoulos A, van Wezel GP, Choi YH, Claessen D, Rozen DE, is organized by a division of labor through terminal genomic differentiation. Sci Adv, 6(3):eaay5781(2020) [pubmed]

submitter keyword: Division of labour, Chromosome change, Bacteria social behavior, Antibiotics over-production, Streptomyces coelicolor,

Gilles P. van Wezel
contact affiliation	Institute of Biology Leiden, Leiden University
contact email	g.wezel@biology.leidenuniv.nl
lab head
Chao DU
contact affiliation	Leiden University
contact email	c.du@biology.leidenuniv.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD014413

PRIDE project URI

• PRIDE
  1. PXD014413
     1. Label: PRIDE project
     2. Name: Proteomics survey of Streptomyces coelicolor strains with natural gross chromosome change