⮝ Full datasets listing

PXD014350

PXD014350 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQUANTITATIVE SUBCELLULAR PROTEOMICS OF THE ORBITOFRONTAL CORTEX OF SCHIZOPHRENIA PATIENTS
DescriptionWe analyzed OFC post-mortem brain tissue from patients classified as residual schizophrenia according to the DMS-IV manual. In this classification, the patients do not manifest prominent positive psychotic symptoms but prevail characteristic disturbance of negative symptoms. Through the comparison of patient´s samples against a pool of control subjects without any history of psychiatric illness we generated an organellar proteome map from different subcellular fractions such as mitochondria (MIT), crude nuclear fraction (NUC) and cytoplasm (CYT) with the aim to monitor the subproteome changes using iTRAQ labelling for relative quantification and Selected Reaction Monitoring (SRM) for targeted quantification.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:11:30.484.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterProteomics Unit
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-06-24 02:37:22ID requested
12019-10-07 02:12:55announced
22024-10-22 04:11:35announced2024-10-22: Updated project metadata.
Publication List
10.1021/acs.jproteome.9b00398;
Vel, á, squez E, Martins-de-Souza D, Vel, á, squez I, Carneiro GRA, Schmitt A, Falkai P, Domont GB, Nogueira FCS, Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients. J Proteome Res, 18(12):4240-4253(2019) [pubmed]
Keyword List
submitter keyword: cellular fractions, proteomics,Schizophrenia, quantification
Contact List
Fabio Nogueira
contact affiliationDepartment of Biochemistry, Institute of Chemistry, Federal university of Rio de Janeiro
contact emailfabiocsn@gmail.com
lab head
Proteomics Unit
contact affiliationUFRJ
contact emailunidadeproteomica@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD014350
PRIDE project URI
Repository Record List
[ + ]