PXD014333

PXD014333 is an original dataset announced via ProteomeXchange.

Title	Sperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier
Description	Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the immune system. This assumption underlies the pursuit of cancer testis antigens (CTAs) as therapeutic targets and biomarkers for particular cancers. CTAs are aberrantly expressed in cancer but only expressed in sperm in healthy men; thus these proteins are assumed to be absent from the blood and/or to be neoantigens.
HostingRepository	PRIDE
AnnounceDate	2021-04-01
AnnouncementXML	Submission_2021-03-31_20:32:55.056.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-21 01:38:21	ID requested
⏵ 1	2021-03-31 20:32:56	announced

O'Donnell L, Rebourcet D, Dagley LF, Sgaier R, Infusini G, O'Shaughnessy PJ, Chalmel F, Fietz D, Weidner W, Legrand JMD, Hobbs RM, McLachlan RI, Webb AI, Pilatz A, Diemer T, Smith LB, Stanton PG, Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men. FASEB J, 35(3):e21397(2021) [pubmed]

submitter keyword: cancer-testis antigens, testicular interstitial fluid, germ cell proteins

Peter Stanton
contact affiliation	Senior Research Fellow Head, Male Fertility Regulation Laboratory
contact email	peter.stanton@hudson.org.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD014333

PRIDE project URI

• PRIDE
  1. PXD014333
     1. Label: PRIDE project
     2. Name: Sperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier