PXD014281

PXD014281 is an original dataset announced via ProteomeXchange.

Title	Endogenous Peptides from Bombyx Batryticatus
Description	Bombyx batryticatus, the dried larva of Bombyx mori L. (4th–5th instars) infected with Beauveria bassiana Vuill, is an important animal-derived medicine effective against several diseases. The metamorphosis of silkworm can result insignificant changes in the levels of proteins and polypeptides in the 4th and 5th instar larvae. Here, we performed extensive characterization of Bombyx batryticatus peptides, including polypeptides containing cysteines, using an MS-based data mining strategy. A total of 779 peptides with various PTMs (post-translational modifications) were identified through database search and de novo sequencing. Some of these peptides might have important biological activities. Besides, the differential analysis of polypeptides between the head and body of Bombyx batryticatus was performed to provide a clinical basis for rational use of the drugs derived from it. This study illustrates the abundance and sequences of endogenous Bombyx batryticatus polypeptides, and thus, provides potential candidates for the screening of active compounds for future biological research and drug discovery studies.
HostingRepository	iProX
AnnounceDate	2018-08-30
AnnouncementXML	Submission_2019-06-17_21:26:49.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yunpeng Bai
SpeciesList	scientific name: Bombyx mori; NCBI TaxID: 7091;
ModificationList	acetylated residue; deaminated residue; iodoacetamide derivatized residue; monomethylated residue; methionine oxidation with neutral loss of 64 Da; ubiquitination signature dipeptidyl lysine
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-17 21:24:43	ID requested
⏵ 1	2019-06-17 21:26:51	announced

Bai Y, Zhao Q, He M, Ye X, Zhang X, Extensive characterization and differential analysis of endogenous peptides from Bombyx batryticatus using mass spectrometric approach. J Pharm Biomed Anal, 163():78-87(2019) [pubmed]

submitter keyword: peptidomics, Bombyx Batryticatus, cysteine tagging, differential analysis

Xiaozhe Zhang
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	zhangxz@dicp.ac.cn
lab head
Yunpeng Bai
contact affiliation	Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	bypnenu@126.com
dataset submitter

iProX dataset URI