PXD014275

PXD014275 is an original dataset announced via ProteomeXchange.

Title	The impact of Bisphenol A on immunity and asthmatic inheritance revealed from a major proteomics study
Description	Environmental estrogens, such as bisphenol A (BPA) that is normally used in the manufacture of food and beverage containers, pose increasingly worrisome hazards to human and wildlife health. The adverse effects of BPA are multifaceted; while close attention has been paid to their effect on the immune response system, especially the possible etiology of asthma in children and adults. The underlined mechanism of how BPA influences the biological pathways that alters the normal immune response system is unknown. Here, we report to use various proteomics and biological approaches to identify BPA-targeting proteins and protein pathways in human colonic and CD4+T cell lines and CD4+T cells extracted from mouse spleens. The outcomes of this study revealed that the cellular respiration, phagosome maturation and especially the Sirtuin signaling pathways are among the top canonic or KEGG pathways perturbed by BPA and they are proteome-phenotypic inheritable to multi-generations. Most importantly, a protein palmitoyltransferase, ZDHHC1, was identified as one of the top proteins upregulated by BPA; and further, it was found that ZDHHC1 forms a heterodimer with STING. This novel finding constitutes a mechanistic model better describing how BPA and E2, as well as vitamin D3, are engaged in the immune response of asthma by up-regulating the expression of ZDHHC1 through histone modifications and its down-stream STING signaling pathways.
HostingRepository	PRIDE
AnnounceDate	2019-12-16
AnnouncementXML	Submission_2019-12-16_03:44:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kangling Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-17 05:27:34	ID requested
⏵ 1	2019-12-16 03:44:20	announced

Sowers ML, Tang H, Tian B, Goldblum R, Midoro-Horiuti T, Zhang K, Bisphenol A Activates an Innate Viral Immune Response Pathway. J Proteome Res, 19(2):644-654(2020) [pubmed]

submitter keyword: Bisphenol A, Asthma, Immune Response, Proteomics

Kangling Zhang
contact affiliation	Department of Pharmacology School of Medicine University of Texas Medical Branch at Galveston
contact email	kazhang@utmb.edu
lab head
Kangling Zhang
contact affiliation	University of Texas Medical Branch
contact email	kazhang@utmb.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD014275
     1. Label: PRIDE project
     2. Name: The impact of Bisphenol A on immunity and asthmatic inheritance revealed from a major proteomics study