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PXD014241

PXD014241 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMFSD1 KO Liver - Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation
DescriptionLysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular catabolic end products from the lysosomal lumen to the cytosol is facilitated by polytopic transmembrane proteins which mediate secondary active or passive transport. One of these proteins is MFSD1, a so far uncharacterized lysosomal 12 transmembrane domain-containing family member of the major facilitator superfamily. MFSD1 is, uncommon for a lysosomal membrane protein, not N-glycosylated. It contains a dileucine-based sorting motif that is essential for its transport to lysosomes. Lysosomes from mouse liver of MFSD1 knock-out mice were isolated and analyzed by TMT labelling, as well as whole liver protein extracts, both in comparison to wildtype controls.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:54:08.379.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMelanie Thelen
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; S-carboxamidoethyl-L-cysteine; monohydroxylated residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-06-13 01:08:41ID requested
12021-03-04 12:10:54announced
22024-10-22 04:54:08announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: lysosome, liver,MFSD1
Contact List
Melanie Thelen
contact affiliationUniversity Hospital Bonn Institute for Biochemistry and Molecular Biology Nussallee 11 53115 Bonn Germany
contact emailmthelen@uni-bonn.de
lab head
Melanie Thelen
contact affiliationInstitute for Biochemistry and Molecular Biology, University Bonn, Germany
contact emailmthelen@uni-bonn.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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