PXD014228

PXD014228 is an original dataset announced via ProteomeXchange.

Title	Effects of N-acetylcysteine on the neurotoxicity induced by acute exposure to acrylamide
Description	In this study, we used the adult zebrafish model of ACR acute neurotoxicity for determining the suitability of NAC to protect the brain against ACR toxicity. First, the potential protective effects of NAC on the ACR neurotoxicity were evaluated at the behavioral and molecular (transcriptome and proteome) levels. Then, in order to understand the mild to negligible protective effect of NAC, the ability of this drug to cross BBB by passive diffusion was evaluated by different approaches. Whereas the BBB parallel artificial membrane permeability assay (BBB-PAMPA) was used to determine the ability of NAC to cross BBB-like phospholipid membranes by passive diffusion, the determination of the NAC content in the brain provides direct evidences of the BBB permeability in vivo. Finally, we evaluated the ability of drug to recover the depleted GSx stores and to scavenge ACR in the brain of ACR-exposed fish.
HostingRepository	PRIDE
AnnounceDate	2020-05-26
AnnouncementXML	Submission_2020-05-26_14:28:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	S-carboxamidoethyl-L-cysteine; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-12 03:15:29	ID requested
⏵ 1	2020-05-26 14:29:00	announced

Faria M, Prats E, G, ó, mez-Canela C, Hsu CY, Arick MA, Bedrossiantz J, Orozco M, Garcia-Reyero N, Ziv T, Ben-Lulu S, Admon A, G, ó, mez-Oliv, á, n LM, Rald, ú, a D, Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Sci Rep, 9(1):16467(2019) [pubmed]

submitter keyword: Danio, acetylcysteine, acrylamide, neurotoxicity

Demetrio Raldua Perez
contact affiliation	aInstitute for Environmental Assessment and Water Research (IDAEA-CSIC). Jordi Girona, 18. 08034 Barcelona, Spain
contact email	drpqam@cid.csic.es
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@tx.technion.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD014228

PRIDE project URI

• PRIDE
  1. PXD014228
     1. Label: PRIDE project
     2. Name: Effects of N-acetylcysteine on the neurotoxicity induced by acute exposure to acrylamide