PXD014188

PXD014188 is an original dataset announced via ProteomeXchange.

Title	Investigating the Succinylome and Malonylome of Schizophrenia
Description	The succinylome and malonylome of human oligodendrocyte precursors (MO3.13 line) and postmortem brain tissue (whole lysates and mitochondrial enrichments) were studied with shotgun mass spectrometry. The goal was to determine what changes in oligodendrocytes are induced with the addition of the NMDA receptor antagonist MK-801 and compare this with schizophrenia brain tissue; to visualize the changes that antipsychotics have on the succinylome and malonylome and how this may relate to their side effects; to see what changes induced by MK-801 are returned to more control-like levels and how this may relate to mechanisms of drug action; and to see what changes in these PTMs may exist in vivo in patients with schizophrenia compared to healthy controls.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:09:33.564.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bradley Smith
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N6-malonyl-L-lysine; N6-succinyl-L-lysine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-10 01:24:27	ID requested
1	2022-12-02 13:34:42	announced
⏵ 2	2023-11-14 08:09:37	announced	2023-11-14: Updated project metadata.

Smith BJ, Brand, ã, o-Teles C, Zuccoli GS, Reis-de-Oliveira G, Fioramonte M, Saia-Cereda VM, Martins-de-Souza D, Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia. J Pers Med, 12(9):(2022) [pubmed]

submitter keyword: schizophrenia, malonylation,succinylation, mk-801, antipsychotics

Daniel Martins-de-Souza
contact affiliation	Laboratory of Neuroproteomics, Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), R. Monteiro Lobato, 255 – Campinas/SP 13083-862, São Paulo, Brazil
contact email	dmsouza@unicamp.br
lab head
Bradley Smith
contact affiliation	UNICAMP
contact email	a22brad22@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD014188

PRIDE project URI

• PRIDE
  1. PXD014188
     1. Label: PRIDE project
     2. Name: Investigating the Succinylome and Malonylome of Schizophrenia